Combined Modality Radioprotection: The Use of Glucan and Selenium with WR-2721
Abstract
Recent radiation accidents at Chernobyl (U.S.S.R.) and at Goiania (Brazil) have again focused attention on the potential value of agents that could mitigate the biological effects of radiation exposure. Such agents, commonly called radioprotectants, could be valuable not only for individuals whom may be exposed to radiation during accident rescue and/or clean-up activities, but also for astronauts who may be subjected to predictable radiation exposures, and for individuals undergoing radiotherapy. During the past several decades, studies of numerous radioprotective agents have led to the realization that not all radioprotectants mitigate damage through similar mechanisms. Because various radioprotective agents differ in mechanisms of action and in optimal administration of action and in optimal administration times with respect to radiation exposure, the use of multiple agents may in some instances provide significantly better protection than single agents. In the studies described here, combinations of such agents were administered to mice and evaluated for effects on survival enhancement and on hemopoietic recovery. By design, individual agents were used at doses that induce minimal-to-no toxic or performance-degrading side effects.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 1990
- Accession Number
- ADA227554
Entities
People
- Joseph F. Weiss
- Myra L. Patchen
- Thomas J. Macvittie
Organizations
- Armed Forces Radiobiology Research Institute