Arachidonic Acid and Prostaglandins Enhance Potassium-Stimulated Calcium InFlux into Rat Brain Synaptosomes

Abstract

Exogenous administration of arachidonic acid, prostaglandins PGF2 alpha, PGD2 and PGE2 increased potassium-stimulated uptake of calcium in rat brain synaptosomes from the brain of the rat, but had no effect on the basal uptake of calcium. Arachidonic acid-induced uptake of calcium was mediated by its prostaglandin metabolites, because a cylooxygenase inhibitor, indomethacin, inhibited the response. L-Type calcium channel blockers, such as verapamil, diltiazem adn nimodipine, blocked both KCl- and prostaglandin-enhanced potassium-stimulated influx of calcium in the brain. These results suggest that prostaglandins act as a calcium ionophore, through L-type voltage-sensitive calcium channels. Keywords: Arachidonic acid, Brain, Calcium, Prostaglandins, Synaptosomes.

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Document Details

Document Type
Technical Report
Publication Date
Mar 02, 1990
Accession Number
ADA227662

Entities

People

  • S. B. Kandasamy
  • W. A. Hunt

Organizations

  • Armed Forces Radiobiology Research Institute

Tags

Communities of Interest

  • Sensors

DTIC Thesaurus Topics

  • Abstracts
  • Brain
  • Carrier Proteins
  • Cells
  • Inhibition
  • Inhibitors
  • Metabolites
  • New England
  • New York
  • Peripheral Nervous System
  • Potassium
  • Prostaglandin
  • Smooth Muscle
  • Statistical Analysis
  • Synaptosomes
  • Tissues
  • Unsaturated Fats

Fields of Study

  • Biology

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