Cerebral-Body Perfusion Model
Abstract
A lumped parameter model is developed to focus on the dynamic flow and pressure interactions between the cerebral, cardiovascular and the respiration systems. The interrelated pressures and fluxes are excited by left cardiac pressure, by expiration/inspiration fluxes and by pressure exerted on the abdomen. Sensitivity analysis examines changes in pressure and flux at the cerebral carotid arteries and capillaries resulting from a sudden rise to an upright position, changes in inhale/exhale patterns, pressurizing the abdomen, changes in gravity acceleration, changes in blood viscosity and heart frequency. Animal experiments are preformed to validate model predictions and to enable parameter estimations. Keywords: Compartmental modeling, Perfusion flux and pressures; Interaction between cerebral, Respiratory and heart system; Sensitivity analysis.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 1990
- Accession Number
- ADA227851
Entities
People
- J. Bear
- K. Allen
- L. Bunt
- M. Feinsod
- S. Ben-haim
- S. Sorek
Organizations
- Technion – Israel Institute of Technology