Development of an Aquatic Bioassay for Carcinogenicity and Toxicity Testing Using the Medaka (Oryzias latipes) as a Model

Abstract

The primary objective of this study was to help to establish the aquatic bioassay as a valid alternative to rodent carcinogenicity and toxicity testing for use by the U.S. Army to test contaminated ground water and effluents in a rapid, inexpensive manner. The study had two parts: the first to study normal hepatic parenchymal development in the fish species to be used, the medaka, and the second to perform a controlled carcinogenic exposure study using the medaka with documentation of the lesions and neoplasms produced. The results outlined in this report have shown that the protocol used is potentially a rapid method of testing carcinogens using the medaka as a model. (js)

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Document Details

Document Type
Technical Report
Publication Date
Aug 15, 1990
Accession Number
ADA227944

Entities

People

  • Tracie E. Bunton

Organizations

  • Johns Hopkins University

Tags

DTIC Thesaurus Topics

  • Animals
  • Biliary Tract
  • Biomedical Research
  • Cancer
  • Carcinoma
  • Cells
  • Chemistry
  • Endoplasmic Reticulum
  • Endothelial Cells
  • Epithelial Cells
  • Fish
  • Macrophages
  • Medical Personnel
  • Neoplasms

Readers

  • Aquatic Ecology
  • Software Engineering
  • Toxicology/Environmental Toxicology