Muramyl Peptide-Enhanced Sleep: Pharmacological Optimization of Performance
Abstract
The characteristic of sleep observed during infectious disease or after the administration of certain bacterial products or endogenous cytokines is similar to the sleep observed after sleep deprivation. Such results have led to the hypothesis that cytokines and perhaps certain bacterial products are involved in physiological sleep regulation; such substances are termed sleep factors (SFs). Our investigations have led us to propose a biochemical regulatory scheme for sleep in which the somnogenic actions of many putative SFs are linked to each other in the sense that they alter each other's production and/or activity. Over the past four years of this contract, we have described several additional SFs and interconnections between them. These results indicate that new more effective and safer somnogenic agents can be developed. The broad goal of our USAMRDC-supported worked has been to develop the information needed to ascertain if it is reasonable to propose either endogenous SFs or synthetic analogs as potential sleep-inducing agents. (js)
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 1990
- Accession Number
- ADA228220
Entities
People
- James M. Krueger
Organizations
- University of Tennessee