Ion Movements in Shock in Relation to Survival and Its Modifications
Abstract
In order to elucidate the mechanisms of cell injury and to correlate such with ion shifts in tissues, comprehensive physiologic, biochemical, and morphological studies as well as x-ray microanalysis measurements of ions in liver and heart were performed using both in vivo hemorrhagic and bacteremic shock models in rats. In the hemorrhagic shock model, deterioration of physiologic parameters and increases in serum potassium concentrations and decreases in serum calcium concentrations were seen. In the bacteremic shock model, a hypodynamic state increases in the activity of various enzymes released from vital organs, such as the liver or heart, were observed. Morphological results suggested that local production of free radicals from migrating and aggregated leukocytes into the sinusoids of the liver after bacteremia may play a possible role in the hepatocellular injury. In both models, x-ray microanalysis of ions in freeze-dried sections of liver and heart showed increases in sodium, chlorine and calcium and decreases in potassium and phosphorus.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1985
- Accession Number
- ADA228228
Entities
People
- Toshihide Sato
Organizations
- University of Maryland, Baltimore