Chemotherapy of Rodent Malaria

Abstract

A technique is described in this report for the evaluation of drug interactions with combinations containing only one active antimalarial agent. The relative merits of chloroquine-resistant strains of P.berghei and P.yoelii ssp. as laboratory models of P.falciparum are discussed. Blood schizontocidal action of 8 WRAIR compounds and 1 compound from another source is summarised. Data from cross-resistance studies on 29 different sensitive and resistant strains are included. In a series of drug interaction tests to determine the influence of 4 WRAIR compounds on the action of chloroquine against chloroquine- resistant P.yoelii ssp. NS strain, only WR 014044 enhanced the activity of chloroquine. A high degree of synergism was demonstrated with a combination of two different isomers of the floxacrine analog WR 243251.

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Document Details

Document Type
Technical Report
Publication Date
Oct 15, 1988
Accession Number
ADA228273

Entities

People

  • Wallace Peters

Organizations

  • London School of Hygiene & Tropical Medicine

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Alkenes
  • Analogs
  • Animals
  • Antimalarials
  • Chemical Synthesis
  • Chemistry
  • Chemotherapy
  • Classification
  • Laboratory Animals
  • Malaria
  • Oils
  • Plastic Explosives
  • Resistance
  • Security
  • Synergism
  • Tropical Medicine

Fields of Study

  • Biology
  • Chemistry
  • Medicine

Readers

  • Parasitology and Pharmacology of Malaria.