A Comparative Study Regarding the Association of Alpha-2U Globulin with the Nephrotoxic Mechanism of Certain Petroleum-Baswd Air Force Fuels
Abstract
Fisher 344 males rats have a dose and time-dependent renal proximal tubular degeneration induced by certain hydrocarbon compounds. We have used rat strain variation of the alpha-2U globulin molecule and metabolic alteration of the urinary pH as methods to investigate the hydrocarbon-induced nephrotoxic response. Three significant advances have been made during this project: (1) the development of a histochemical procedure to specifically evaluate decalin- induced changes in the lysosomes of rat renal tubular epithelial cells, (2) the discovery that pigmented male rats demonstrate hydrocarbon-induced nephrotoxicity, and (3) the discovery of a difference in the hydrocarbon-induced nephrotoxicity response of male rats following alteration of the urinary pH. Sodium bicarbonate-induced elevation of the urinary pH markedly altered the lysosomal integrity and morphologic appearance of renal tubular cells in male rats exposed to decalin. (JS)
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 17, 1990
- Accession Number
- ADA228540
Entities
People
- Thomas E. Eurell
Organizations
- University of Illinois Urbana–Champaign