Characterization of African Human Retroviruses Related to HTLV-111/LAV
Abstract
Our data on the biology of HIV-2 suggest that this virus may have a distinct biology from that of its close relative HIV-1. It is therefore relevant to assess these differences in populations infected with significant rates of both HIV-2 and HIV-1. Senegal is such a West African country, and the studies established there have provided important new information on the natural history and epidemiology of HIV-2. The prolonged incubation period for HIVs in general suggests that much can be learned from the evaluation of infected individuals over time. This would include: (1) the dynamics and risk factors and transmission, (2) the immune response parameters evaluated over course of infection and their correlation with viral burden and clinical course and (3) evolution of HIV pathogenesis. Our studies conducted to date, have already indicated differences in the above virus-host interactions between HIV-2 and HIV-1. (JS)
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 02, 1990
- Accession Number
- ADA228544
Entities
People
- Phyllis J. Kanki
Organizations
- Harvard T.H. Chan School of Public Health