Cancer Diagnosis by Laser Spectroscopy

Abstract

The objective of this project is to investigate and develop novel optically based diagnostics modalities to distinguish between normal and cancerous tissues using various types of steady state and ultrafast laser spectroscopy. Significant work has been completed over the past year. Raman and fluorescence spectroscopy have been studied for human leukemia and normal white blood cells in the visible spectral region as well as for human benign breast tissues, benign breast tumor and malignant breast tumors in the near infrared region. The Raman lines were observed from normal white blood cells but not from leukemia white blood cells. Using IR Raman scattering different intensities and numbers of Raman active modes were measured for benign and malignant tumor tissues. Our preliminary results suggest a new novel approach to diagnose leukemia and benign and malignant tumor using spectral positions and intensities of Raman lines. (js)

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 1990
Accession Number
ADA228628

Entities

People

  • Robert Alfano

Organizations

  • City College of New York

Tags

DTIC Thesaurus Topics

  • Biological Sciences
  • Blood
  • Blood Cells
  • Breast Cancer
  • Cancer
  • Cells
  • Fluorescence
  • Intensity
  • Laser Spectroscopy
  • Lasers
  • Leukemia
  • Leukocytes
  • Neoplasms
  • New York
  • Raman Scattering
  • Spectroscopy
  • Ultrafast Laser Spectroscopy

Fields of Study

  • Physics

Readers

  • Molecular Photonics/Laser Physics
  • Oncology (Cancer Research).
  • Oncology and Biomarker-Based Cancer Detection.

Technology Areas

  • Directed Energy
  • Directed Energy - Lasers