Effect of Prostaglandin E in Multiple Experimental Models. VII. Effect on Resistance to Sepsis

Abstract

One of the primary aetiologies for mortality following burn injury is the development of infectious complications (Sevitt, 1979). These infections have two main causes, a loss of the skin's natural barrier and the immunosuppression that results from burn injuries. This immunosuppression is due to a number of factors, including inadequate nutrition in the postburn period, the use of immunosuppressive agents such as anaesthesia and blood transfusions, and the release of endogenous immunosuppressive metabolites. Prostaglandin E (PGE) has been reported to be one of the immunosuppressive metabolites released following burn injury (Ninnemann and Stockland, 1984). The belief in an immunosuppressive nature of PGE has resulted from two areas of investigation. (js)

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 1990
Accession Number
ADA228679

Entities

People

  • A.d. Mason Jr
  • B. A. Pruitt Jr.
  • J. P. Waymack
  • R. F. Guzman

Organizations

  • United States Army Institute of Surgical Research

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Amino Acids
  • Blood
  • Blood Transfusions
  • Burns
  • Endotoxins
  • Enzyme Inhibitors
  • Escherichia Coli
  • Immunosuppression
  • Immunosuppressive Agents
  • Infection
  • Inhibitors
  • Medical Personnel
  • Necrosis
  • Prostaglandin
  • Proteins
  • Resistance
  • Wound Infections

Fields of Study

  • Medicine

Readers

  • Gulf War Illness and Chronic Multisymptom Illness in Veterans.
  • Immunology and Pathology
  • Trauma Surgery or Emergency Medicine.