Phosphoprotein Regulation of Behavioral Reactivity

Abstract

The regulation of synaptic reactivity by protein kinase C and its substrates has been studied using the long-term potentation paradigm (LTP). We have studied the effects of protein kinase C activators and inhibitors on the durability of synaptic reactivity. The main conclusion to be drawn is that PKC is necessary but not sufficient for the enhanced durability. In combination with a neural signal, however, PKC demonstrates a profound synergism. Synergism is also observed in the analysis of metal ion regulation of PKC activity. Calcium and zinc interact in their effect on the enzyme in a bidirectional manner. Significant accomplishments made during this period were: determining the effect of inhibitors; the study of PKC activators (PDBu and oleate); metal ion regulation of PKC activity; and a second path for PKC activation. Keywords: Synaptic reactivity, Protein kinase, Activators, Inhibitors, Synergism.

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Document Details

Document Type
Technical Report
Publication Date
Jul 17, 1990
Accession Number
ADA228751

Entities

People

  • Aryeh Routtenberg

Organizations

  • Northwestern University

Tags

Communities of Interest

  • Human Systems
  • Space

DTIC Thesaurus Topics

  • Alzheimer Disease
  • Brain
  • Cellular Structures
  • Chemistry
  • Diseases And Disorders
  • Fatty Acids
  • Medical Personnel
  • Nervous System
  • Neurons
  • Neurosciences
  • Proteins
  • Synapses

Fields of Study

  • Biology

Readers

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  • Cellular and Molecular Pathways of Apoptosis.
  • Neuroscience