Possible Mechanism for Denervation Effect on Wound Healing
Abstract
This report continued basic research on the role of transferrin, an iron-transport protein required for cell proliferation, in the neural effect on wound healing and tissue regeneration. The system of tissue repair under investigation is the regenerating limb of the axolotl, in which growth is strictly dependent on unknown factors from peripheral nerves. The rationale of the study is to quantify transferrin in segments of ligated normal and regenerating nerves in order to obtain information with which to test the hypothesis that axons transport transferrin to cells of the regenerating tissues. Before experiments of this nature can be undertaken, axolotl transferrin and antibodies against this factor had to be produced so that immunoassays could be developed to measure this protein in nerves, regenerating limbs, and other tissues from axolotls. These goals were accomplished in the earlier phase of the project and during the past year the immunoassay was used to obtain data regarding axonal transport and transferrin. (TTL)
Document Details
- Document Type
- Technical Report
- Publication Date
- May 23, 1990
- Accession Number
- ADA228831
Entities
People
- Anthony L. Mescher
Organizations
- Indiana University