Smoke Inhalation Injury and the Effect of Carbon Monoxide in the Sheep Model

Abstract

The role of carbon monoxide (CO) in causing the physiologic and anatomic changes characteristic of smoke inhalation injury was evaluated in 34 sheep. The smoke-exposed group received a dose of smoke known to produce mild inhalation injury. The CO group received a pure gas mixture that contained concentrations of oxygen, carbon dioxide, and CO similar to those in the smoke. Cardiopulmonary function was measured immediately after exposure, and 24 and 72 hours after exposure. The CO group showed a transient increase in cardiac output, but the smoke group showed no such response. The CO group maintained normal PaO2 levels during the 72-hour study period; the smoke group gradually developed hypoxemia. The lugs of the Co exposed animals had no descernible histologic changes. these results indicate that CO perse is not the primary etiologic agent of smoke inhalation injury. (js)

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 1990
Accession Number
ADA228858

Entities

People

  • Arthur D. Mason
  • Gene B. Hubbard
  • Hisashi Ikeuchi
  • Paulette C. Langlinais
  • Takeshi Shimazu

Organizations

  • United States Army Institute of Surgical Research

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Airway Management
  • Blood Gases
  • Burns
  • Carbon Dioxide
  • Carbon Monoxide
  • Cardiovascular Physiological Phenomena
  • Dielectric Gases
  • Gases
  • Inhalation Burns
  • Poisoning
  • Respiration
  • Respiratory Physiological Phenomena
  • Wounds And Injuries

Readers

  • Cardiovascular Physiology
  • Toxicology/Environmental Toxicology