IGG Subclass and Isotype Specific Immunoglobulin Responses to Lassa Fever and Venezuelan Equine Encephalomyelitis: Natural Infection and Immunization
Abstract
Venezuelan equine encephalitis (VEE) specific immunoglobulin responses to the two vaccines, TC-83 (a live attenuated vaccine) and C-84 (a formalin inactivated vaccine derived from the TC-83 strain) were evaluated using an antigen and isotype specific enzyme-linked immunoadsorbent assay (ELISA). As previously described, the assays were standardized in methodology and in relation to a uniform reference curve prepared from a pool of subjects with high titers of 80% PR-VNA (80% plaque reduction in the viral neutralization assay). Time-course SERA before and following varying schedules of TC-83 and/or C-84 vaccine were tested suggesting a trend of improved responses to live attentuated vaccine (particularly with IgA and IgM) compared to the killed vaccine. Subject Terms: Venezuela equine encephalitis; immunoglobulin.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 30, 1990
- Accession Number
- ADA228963
Entities
People
- Renata J. Engler
Organizations
- Uniformed Services University of the Health Sciences