T Cell Responses to Arenavirus Infections

Abstract

Experimental evidence suggests that immunity to the Old World arenavirus, Lassa virus, is mediated by T cells. The related arenavirus, lymphocytic choriomeningitis virus (LCMV), cross-protects animals against lethal challenge with Lassa virus and animals cured of Lassa by ribavirin are protected against lethal challenge with LCMV. Thus, arenaviruses share protective antigenic determinants that are located on homologous regions of structural proteins. We tested a recombinant vaccinia virus which expresses the envelope glycoprotein precursor (GP-C) of Lassa virus (V-LSGP-C) for its ability to cross-protect mice against lethal challenge with LCMV, and have tried to locate T cell determinants.

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Document Details

Document Type
Technical Report
Publication Date
May 10, 1989
Accession Number
ADA228990

Entities

People

  • Gerald A. Cole
  • Vincent J. La Posta

Organizations

  • University of Maryland, Baltimore

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Amino Acids
  • Blood
  • Cell Line
  • Cells
  • Classification
  • Computer Programs
  • Cultured Cells
  • Diseases And Disorders
  • Glycoproteins
  • Immunity
  • Lymphatic System
  • Lymphocytes
  • Molecules
  • Proteins
  • Rodents
  • Viruses
  • Word Processors

Fields of Study

  • Biology

Readers

  • Virology (or Medical Virology).

Technology Areas

  • Space