Behavior, Immunologic Response, and Upper Respiratory Infection

Abstract

Our study involves predicting infection and symptomatology in humans from psychological status, health behaviors, and immunologic measures taken prior to a viral challenge (Rhinoviruses 2, or 9, or 14). Subjects in the viral challenge trials were 302 volunteers kept in isolation and monitored closely for viral shedding, and symptomatology over nine-day trial. We also collected cross- sectional data on psychological and behavioral characteristics and immune status from an additional 385 volunteers (total of 687 for analyses of these data). ONR funds were used to (a) examine the usefulness of antibody levels to Herpes Simplex Virus 1 (HSV-1) as an indirect measure of cellular immune function in this context; and (b) to examine the influence of smoking status and rate (as assessed by serum cotinine) on immunity and susceptibility to infection.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 1990
Accession Number
ADA228996

Entities

People

  • Sheldon Cohen

Organizations

  • Carnegie Mellon University

Tags

DTIC Thesaurus Topics

  • Antigens
  • Blood
  • Blood Cells
  • Cells
  • Classification
  • Education
  • Human Behavior
  • Leukocytes
  • Lung Diseases
  • Lymphocytes
  • Medical Personnel
  • Proteins
  • Public Health
  • Respiration Disorders
  • Respiratory Tract Diseases
  • Security

Fields of Study

  • Biology

Readers

  • Mental Health of Military Veterans with Posttraumatic Stress Disorder (PTSD): Risk Factors, Prevalence, Symptoms, and Treatment.
  • Psychological Intervention/Treatment for Stress, Anxiety, PTSD, and Related Emotional and Cognitive Health Symptoms.
  • Virology (or Medical Virology).