Nerve Growth Factor Effects on the Immune System

Abstract

In the present phase of our study, we have investigated the relationship between the nerve growth factor protein (NGF) and the hypothalamus- pituitary-adrenocortical axis (HPAA), a neuroendocrine system active in the response to stress and the immune system. We found that NGF is not able to stimulate the release of corticosterone from the adrenal glands in rats bearing a pharmacological block of the hypothalamus. Also, this activation of the HPAA can be reduced with anti-NGF. Thus, the stimulatory action of NGF on HPAA requires adrenocorticotropic hormone secretagogues release from the hypothalamus and that NGF modulates HPAA function. (js)

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Document Details

Document Type
Technical Report
Publication Date
Nov 15, 1990
Accession Number
ADA229052

Entities

People

  • J. R. Perez-polo

Organizations

  • University of Texas Medical Branch

Tags

DTIC Thesaurus Topics

  • Acquisition
  • Adrenal Glands
  • Availability
  • Cell Line
  • Cells
  • Classification
  • Growth Factors
  • Hippocampus
  • Hormones
  • Hypothalamus
  • Nerves
  • Nervous System
  • Neurons
  • Neurosecretory Systems
  • Pituitary And Hypothalamic Hormones And Analogues
  • Proteins
  • Security

Fields of Study

  • Biology

Readers

  • Cardiovascular Physiology
  • Cellular and Molecular Pathways of Apoptosis.