Receptor Binding and Membrane Transport of Botulinum Toxins

Abstract

The goal of this research is to characterize the interaction of the botulinum type neurotoxins with target membranes and seeks to add to the field of study of toxin/cell interactions. Also, this research project seeks to determine any similarity between the mechanism of action of botulinum toxins and a number of other protein toxins whose mechanism of action has been more clearly defined. Through the utilization of antibodies to a series of diverse protein toxins and an artificial liposome target system for the botulinum toxin, it is hoped that the mechanism of action of the toxin can be better defined. Also, this will allow us to gain an understanding of how to inhibit the action of this toxin. (JS)

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Document Details

Document Type
Technical Report
Publication Date
Mar 01, 1989
Accession Number
ADA229063

Entities

People

  • John R. Dankert

Organizations

  • University of Florida

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Abstracts
  • Acids
  • Amino Acids
  • Antibodies
  • Biomedical And Dental Materials
  • Classification
  • Films
  • Gel Electrophoresis
  • Hormones
  • Inhibition
  • Inhibitors
  • Materials
  • Membranes
  • Molecules
  • Polymers
  • Proteins
  • Synthetic Membranes

Fields of Study

  • Computer science

Readers

  • Molecular and Cellular Biochemistry
  • Theoretical Analysis.