Complex Cognitive Performance and Antihistamine Use
Abstract
Research has demonstrated that the majority of antihistamines (H1 antagonists) have sedative effects and can impair psychomotor performance; however, it is claimed that astemizole (hismanal) does not possess central nervous system side effects. A two-factor, repeated measures, double-blind design was used to compare the effects of three treatments (two antihistamines and one placebo) on cognitive information processing, mood, selected physiological measures, subjective feelings of drowsiness, and subjective performance rating in 28 healthy men. Evaluations were given at 1,3,5,7,9,11,13 and 15 hours post ingestion. Time-of-day effects were evident in following directions, unstable tracking, code substitution, serial addition/subtraction, logical reasoning, manikin, and pattern comparison tasks. (js)
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 01, 1990
- Accession Number
- ADA229120
Entities
People
- Harry S. Snyder
- Valerie J. Rice
Organizations
- Virginia Tech