Control of Cytokine Gene Expression in Macrophages: Role of Second Messenger Pathways

Abstract

Several cytokines are produced by IL-2 stimulated PBL and many of these mediators are capable of either directly or indirectly inducing fibroblast proliferation and connective tissue (collagen) deposition. It has been shown that macrophages, for example, produce several factors for fibroblast, including interleukin-1 (IL-1; Schmidt et al, 1982), tumor necrosis factor-alpha platelet derived growth factor, fibroblast growth factor. Two of these cytokines, TG and PDGF are highly fibrogenic. Aberrant production of these mediators in animal models of lung fibrosis have demonstrated that activated macrophages secret cytokines which induce the proliferation of cultured fibroblasts.

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Document Details

Document Type
Technical Report
Publication Date
Nov 01, 1990
Accession Number
ADA229181

Entities

People

  • Elizabeth J. Kovacs

Organizations

  • Loyola University Chicago

Tags

DTIC Thesaurus Topics

  • Anti-Bacterial Agents
  • Blood
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Collagen
  • Connective Tissue
  • Culture Techniques
  • Cultured Cells
  • Fibroblasts
  • Gene Expression
  • Growth Factors
  • Peptide Growth Factors
  • Peptides
  • Proteins
  • Tissues

Fields of Study

  • Medicine

Readers

  • Immunology and Pathology