Synthesis of Nucleoside Analogues with Potential Antiviral Activity against Negative Strand RNA Virus Targets
Abstract
The work described here is an attempt to synthesis nucleoside analogues which are targetted against the replicase of negative-strand viruses. Two lines of investigation have been attempted: (i) the synthesis of 5-vinyl substituted pyrimidine ribonucleosides and (ii) the synthesis of potential nucleotide pro-drugs. A series of compounds of type (i) have been synthesised and submitted for biological evaluation. Strategies for the synthesis of compounds of type (ii) have been developed but we have not had time to prepare sufficient suitable material for testing purposes. (js)
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 01, 1989
- Accession Number
- ADA229411
Entities
People
- Richard T. Walker
Organizations
- University of Birmingham