Subcellular Signal Transduction Systems in the Cellular Trauma of Ischemia

Abstract

The formation of sphingosine,a potent inhibitor of protein kinase C, has been characterized in cell models of interest to studies of hypoxic and ischemic injury. With J775 macrophages, we find that sphingosine is released in an acidic compartment and is inhibitable by ammonium ion, an agent that is well known to accumulate during ischemia. The increase in sphingosine is correlated with inhibition of protein kinase C; therefore, these findings may provide a link between changes in ammonia in vivo and alteration in cell function.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Nov 24, 1990
Accession Number
ADA229876

Entities

People

  • Alfred H. Merrill Jr

Organizations

  • Emory University

Tags

DTIC Thesaurus Topics

  • Biochemistry
  • Biological Sciences
  • Cell Physiological Processes
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Dielectric Gases
  • Fatty Acids
  • Health Services
  • Internal Medicine
  • Lipids
  • Macrophages
  • Metabolism
  • Military Research
  • Programmed Cell Death
  • Proteins
  • Surgery

Fields of Study

  • Biology

Readers

  • Analytical Chemistry
  • Breast cancer cell signaling and growth regulation.
  • Immunology and Pathology