Mechanism of Action of Ribavirin on Bunyavirus Infected Cells

Abstract

Ribavirin (1-B-D-ribofuranosyl-1,2,4-triazole-3-carboxamide) or Virazole is a broad-spectrum antiviral agent whose molecular mode of action remains remarkably controversial. The drug was approved by the Food and Drug Administration in 1986 for aerosol use in infants with serious infections due to respiratory syncytial virus (RS) Ribavirin is and has been under clinical investigation against a variety of viral illness, including those due to influenza virus, Lassa fever, Korean hemorrhagic fever with renal sydrome (KHFS) and human immunodeficiency virus (HIV). There has been a great deal of clinical interest in utilizing ribavirn for HIV infections. It has been reported to slow the development of AIDS in HIV infected patients (1). We described here the major mechanisms of actions of this newly licensed drug. (js)

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 1990
Accession Number
ADA230013

Entities

People

  • Jean L. Patterson

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Acquired Immune Deficiency Syndrome
  • Antiviral Agents
  • Cells
  • Chemistry
  • Encephalitis
  • Equine Encephalitis
  • Health Services
  • Hiv Infections
  • Infectious Diseases
  • Interferon
  • Materials
  • Nucleic Acids
  • Proteins
  • Rna Viruses
  • Virus Diseases
  • Viruses
  • Zoonoses

Fields of Study

  • Medicine

Readers

  • Oncology
  • Virology (or Medical Virology).