An Experimental Brain Missile Wound: Ascertaining Pathophysiology and Evaluating Treatments to Lower Mortality and Morbidity

Abstract

Chemical regulation of CBF: Normoxic hypocapnia (PaCO to the second power 21 mmHg) significantly reduced total CBF and many rCBFs both before and after wounding but after wounding this response may have been attenuated except around the wound track where CBF reduction was enhanced. Effect of wounding on selected physiologic variables which might account for death. The effect of brain wounding on lung water was insignificant. The effect increased intracranial pressure on brain biogenic amines. The monoaminergic neurotransmitters (EPI, NE, 5-HT) and some their metabolities (DOPAC, HVA, 5-HIAA) were evaluated in selected brain stem areas and the hypothalamus after increases in ICP sufficient to elicit an immediate Cushing response.

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Document Details

Document Type
Technical Report
Publication Date
Oct 26, 1990
Accession Number
ADA230062

Entities

People

  • Dan Torbati
  • J. B. Farrell
  • Joweph Soblosky
  • June Davidson
  • Michael E. Carey

Organizations

  • LSU Health Sciences Center New Orleans

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Amines
  • Arteries
  • Blood
  • Brain
  • Brain Injuries
  • Cardiovascular Diseases
  • Cardiovascular Physiological Phenomena
  • Cardiovascular System
  • Chemistry
  • Craniocerebral Trauma
  • Data Analysis
  • Neurons
  • Neurosciences
  • Respiration Disorders

Readers

  • Cardiovascular Physiology
  • Trauma Surgery or Emergency Medicine.