Frontal Decortication and Adaptive Changes in Striatal Cholinergic Neurons: Neuropharmacological and Behavioral Implications

Abstract

Molecular Mechanism studies: autoradiographic and saturation binding experiments showed a marked reduction of (3H) hemicholinium-3(3H)HCh-3 binding to sodium-dependent high-affinity choline uptake (SDHACU) sites in striatum two weeks after frontal decortication. Oxiracetam (100 mg/kg i.p.), a nootropic drug, did not affect the distribution of (3H)HCh-3 binding sites in sham-operated rats but completely overcame the reduction in the Bmax of decorticated striatum. This result is consistent with the increase in SDHACU in decorticated striatum after oxiracetam treatment. Frontal decortication did not change the percentage of the mAChR subtypes M1 and M3 present in the striatum and did not affect Gpp(NH)p modulation of binding affinity for the muscarinic cholinergic agonist oxotremorine (OTMN) in the striatum. Frontal decortication did not affect the activation of phosphoinositide turnover (PI) induced by carbachol but it enhanced the stimulation of PI turnover induced by ibotenic acid, a glutamatergic agonist.

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Document Details

Document Type
Technical Report
Publication Date
Sep 28, 1990
Accession Number
ADA230132

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  • Silvana Consolo

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  • Mario Negri Institute for Pharmacological Research

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