The Complexity of DRw6 DR5 Haplotypes in American Blacks Demonstrated by Serology, Cellular Typing, and Restriction Fragment Length Polymorphism Analysis
Abstract
The class II region of the human major histocompatibility complex encodes highly polymorphic heterodimeric cell surface glycoproteins (DR, DQ, and DP), which function in the induction of the normal immune response and are responsible in part for allograft rejection and autoimmune disease susceptibility. The polymorphic residues of the class II polypeptides are localized to the amino terminal domains and are clustered into variable regions. In the predicted three-dimensional structure of the class II molecule, the majority of the polymorphic sites reside in the antigen-binding T-cell receptor recognition site suggesting the importance of these residues in controlling antigen recognition and allograft rejection. HLA-D regions that encode molecules carrying DR serologic determinants share general structural features suggesting a common origin. The DRw52 subregion of most of these haplotypes encodes one nonpolymorphic gene (DRA) and three DR genes.
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 01, 1990
- Accession Number
- ADA230144
Entities
People
- Armead H. Johson
- Carolyn K. Hurley
- Kyung W. Lee
- Robert Hartzman
Organizations
- Naval Medical Research Center