Bridged Bicyclic Systems and Pretreatment Drugs as Acetylcholinesterase Reactivators
Abstract
During the past year, (+) and (-) 2-oximinotropan-3-one methiodides have been synthesized as well as the racemic compound (+) 2-oximinotropan-3-one methiodide. The regioisomeric (+) and (-) 3-oximinotropan-3-one methiodides have also been synthesized. Binding constants to AChE, pKa's and reactivation activities for these compounds have been determined. Atropine-like 3-acetophenyl tropine oxime hydrochloride has been synthesized and submitted for testing. Syntheses of 4-(1-piperidinyl)-4-pheylcyclohexanone oxime methiodide, 1-(1- phenylcyclohexyl)-4-piperidone oxime methiodide and 2-benzylidene-3- quinuclidinone oxime hydrochloride have been achieved.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 15, 1989
- Accession Number
- ADA230203
Entities
People
- Robert M. Moriarty
Organizations
- University of Illinois at Chicago