Towards Wound Closure Optimization
Abstract
Extensive experimentation with many combinations of lasers and chromophores was conducted to determine the optimal parameters for laser tissue welding. New Zealand White rabbit small bowel was used as an in vitro model for this study. The analysis indicates that particular chromophores can be utilized to enhance the effectiveness of certain lasers. For example, India ink is an effective chromophore for the 1.06 micron Nd:YAG laser, while blood is most effective for the 0.514 micron Ar ++ laser. The 2.1 micron Ho:YAG laser produced strong chromophore-free welds, and also produced strong welds in the presence of India ink and blood. The laser welding literature indicates that Indocyanine Green is an adjuvant to laser welding with the 0.808 micron Ga:Al:As diode laser. The diode lasers that were examined in this study did not provide sufficient energy to weld tissue and evaluate these statements. Indocyanine Green did prove to be an effective chromophore for the 0.532 micron KTP laser. The apparatus designed and developed for this study provides an unique method to determine the laser tissue welding parameters which will produce the strongest welds.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 15, 1991
- Accession Number
- ADA230971
Entities
People
- Larry I. Sanders