Interferon Inducers against Infectious Diseases

Abstract

A series of interferon inducers was developed, in which carboxymethyl cellulose (the undesired component of poly ICLC) was replaced by other anionic polymers or by graft polymers of poly(L-lysine) with saccharides. Most of these showed effective antiviral action against Rift Valley Fever virus and Punta Toro virus. Most were less toxic than poly ICLC and were non-immunogenic. The promising replacements for carboxymethylcellulose are: carboxymethylamylose, carboxymethyl Beta cyclodextrin, gelatin, sulfated gelatin, sulfated Beta cyclodextrin, poly(lysine)-dextran graft, and poly(lysine)-glucose graft.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Jul 13, 1990
Accession Number
ADA231360

Entities

People

  • Jake Bello
  • Judith O'malley

Organizations

  • Roswell Park Comprehensive Cancer Center

Tags

DTIC Thesaurus Topics

  • Biomedical And Dental Materials
  • Blood
  • Body Weight
  • Carbohydrates
  • Carboxymethylcellulose
  • Chemical Synthesis
  • Chemistry
  • Infectious Diseases
  • Molecules
  • Organic Chemistry
  • Organic Compounds
  • Polymer Chemistry
  • Polymers
  • Polysaccharides
  • Rift Valley Fever
  • Rift Valleys
  • Viruses

Fields of Study

  • Biology

Readers

  • Molecular and Cellular Biochemistry
  • Polymer Science and Technology
  • Virology (or Medical Virology).