Interactions Among Drinking and Ground Water Contaminants on Renal and Hepatic Function

Abstract

This project was designed to elaborate on possible effects on monochloroacetate (MCA), maleic acid (MA) and dichloromaleic acid (DCMA) on liver and kidney function. These studies have revealed important interactions between these test compounds and various known hepato- and nehphrotoxicants. Some of the interactions were of a potentiative nature and some were antagonistic. In addition, chromate appears to enhance the nephrotoxicity of some of these test compounds, an observation consistent with earlier studies in this report on the interactions of chromate with other substances. All of the studies in this report suggest an important role in the tissue non-protein sulfhydryls.

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Document Details

Document Type
Technical Report
Publication Date
Jan 03, 1991
Accession Number
ADA231751

Entities

People

  • William O. Berndt

Organizations

  • University of Nebraska Medical Center

Tags

DTIC Thesaurus Topics

  • Acids
  • Air Force
  • Alkenes
  • Animals
  • Carbon Tetrachloride
  • Cells
  • Chlorides
  • Chloroform
  • Chromium Compounds
  • Digestive System Processes
  • Drinking Water
  • Environmental Pollutants
  • Groundwater
  • Maleic Acid
  • Metabolites
  • Potassium Dichromate
  • Toxicity

Readers

  • Computational Modeling and Simulation
  • Organic Chemistry
  • Toxicology/Environmental Toxicology