ESR Study of Electron Transfer Reactions between gamma-Irradiated Pyrimidines, Adriamycin and Oxygen

Abstract

The direct effect of ionizing radiation on DNA generates mainly guanine and thymine radicals. These radicals have been observed in solid DNA samples using electron spin resonance (ESR) spectroscopy. However, the exact fate of the guanine and thymine radicals when DNA is in solution is still unclear. One possibility of interest to this work, is the reaction of these radicals with other molecules in the solution generating products which may be harmful to cells. For this reason and as a model, the reaction between Gamma-irradiated pyrimidine bases with adriamycin was studied.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 1990
Accession Number
ADA231832

Entities

People

  • Alasdair J. Carmichael
  • Carmen M. Arroyo

Organizations

  • Armed Forces Radiobiology Research Institute

Tags

Communities of Interest

  • Energy and Power Technologies

DTIC Thesaurus Topics

  • Abstracts
  • Chemical Reactants
  • Chemistry
  • Electron Spin Resonance
  • Electron Transfer
  • Electrons
  • Free Radicals
  • Ionizing Radiation
  • Magnetic Fields
  • Nucleic Acids
  • Nucleosides
  • Paramagnetic Resonance
  • Radiation
  • Resonance
  • Spectra
  • Spectroscopy
  • Spin Resonance

Fields of Study

  • Chemistry

Readers

  • Combustion science or combustion engineering.
  • Materials Science and Engineering.
  • Molecular and genetic basis of cancer.

Technology Areas

  • Microelectronics