Function of Bacterial Spore Coat Polypeptides in Structure, Resistance and Germination

Abstract

The spore coat of Bacillus subtilis is comprised of two morphological layers each consisting of several polypeptides. One which was cloned and sequenced is processed from a precursor. A deletion of this gene resulted in some alteration in the structure of the inner coat and of the capacity to respond to a specific spore germinant. When this protein was over produced from a multicopy plasmid, the spores had a thickened inner coat and germinated poorly. The absence of another spore coat protein had extensive pleiotropic effects on the assembly of the outer spore oat. As a result, the spores were lysozyme-sensitive but they germinated at rates similar to the wild type.

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Document Details

Document Type
Technical Report
Publication Date
Dec 20, 1990
Accession Number
ADA232217

Entities

People

  • Arthur I. Aronson

Organizations

  • Purdue Research Foundation

Tags

Communities of Interest

  • Air Platforms

DTIC Thesaurus Topics

  • Alanine
  • Amino Acids
  • Anti-Bacterial Agents
  • Antibodies
  • Assembly
  • Bacteria
  • Biological Sciences
  • Cells
  • Chemistry
  • Construction
  • Enzymes
  • Genetic Code
  • Genetics
  • Military Research
  • Protein Sequence Analysis
  • Proteins
  • Spores

Readers

  • Military/Explosive Ordnance Disposal (EOD) Technology
  • Molecular Genetics