Acute Oral Toxicity of 3-Chloro-4,4-dimethyl-2-oxazolidinone (Compound 1) in ICR Mice
Abstract
The acute oral toxicity of 3-chloro-4, 4-dimethyl-2-oxazolidinone (Compound 1) was determined in male and female ICR mice by using the oral gavage single-dose method. The median lethal dose was 309 mg/kg for male and 332 mg/kg for female mice. The predominate clinical observation was a syndrome of generalized malaise which are characterized by inactivity, hunched posture, and rough coat. This syndrome was observed at all dose levels with frequency and severity increasing with dose. One finding of note at the higher dose levels was the presence of hematuria; however, there was no obvious evidence of rental pathology observed at necropsy. Lethality was observed primarily during the first 48 hours after dosing and most of the clinical signs were also observed during this time period. These results place 3-chloro-4, 4-dimethyl-2- oxazolidinone in the very toxic category.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 1990
- Accession Number
- ADA232778
Entities
People
- Carolyn M. Lewis
- Conrad R. Wheeler
- Don W. Korte Jr.
- Gerald F. Hiatt
Organizations
- Letterman Army Hospital