Drug Evaluation in the Plasmodium falciparum - Aotus Model

Abstract

The objective of these studies was to evaluate experimental antimalarial drugs in the Panamanian night monkey (Aotus 1. lemurinus) experimentally infected with Plasmodium falciparum. Four folic acid inhibitors were tested against infections of the pyrimethamine-resistant Vietnam Smith strain. Of the four drugs evaluated, pyrimethamine, proguanil, cycloguanil, and a proguanil analog (WR 250417), only the proguanil analog had antimalarial activity. A total 3.0 mg/kg dose cured infections in 3 to 7 treatments, a 30.0 mg/kg total dose cured 6 infections out of 8 treatments, and a total dose of 150.0 mg/kg cured infections in 4 of 4 treatments. Six calcium channel blockers were administered with chloroquine in trials to reverse chloroquine-resistance in vivo of Vietnam Smith/RE infections. Only desipramine cleared primary parasitemias but did not cure infections.

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Document Details

Document Type
Technical Report
Publication Date
Dec 12, 1990
Accession Number
ADA232854

Entities

People

  • Richard N. Rossan

Tags

DTIC Thesaurus Topics

  • Antimalarials
  • Biological Pigments
  • Body Weight
  • Chlorpromazine
  • Classification
  • Contracts
  • Drug Combinations
  • Inhibitors
  • Malaria
  • Medical Personnel
  • Parasitic Diseases
  • Peroxides
  • Phenothiazines
  • Pyrimethamine
  • Resistance
  • Security
  • Test And Evaluation

Fields of Study

  • Medicine

Readers

  • Parasitology and Pharmacology of Malaria.