The Molecular Anatomy of PFDA Hepatotoxicity as Studied by Two- Dimensional Electrophoresis.

Abstract

Perfluoro-n-decanoic acid (PFDA) effects on protein expression in the rat liver were studied in rodents following in vivo exposure to PFDA levels above, below and at the LD-50. Two-dimensional whole-liver homogenate protein patterns were generated and compared to previous results. As before, numerous proteins were altered; some suppressed, some induced, but most were unaffected. In an effort to identify the altered proteins, further analysis off basic proteins by first-dimension NEPHGE revealed the induction of cytochrome P452 (lauric acid -oxidase) and enoyl-CoA hydratase.

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Document Details

Document Type
Technical Report
Publication Date
Jan 03, 1991
Accession Number
ADA232958

Entities

People

  • Frank A. Witzmann

Tags

DTIC Thesaurus Topics

  • Anatomy
  • Biological Sciences
  • Body Weight
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Classification
  • Cytochromes
  • Fatty Acids
  • Microsomes
  • Mitochondria
  • Molecular Weight
  • Proteins
  • Security
  • Toxicology
  • Two Dimensional
  • Universities

Fields of Study

  • Biology

Readers

  • Cellular and Molecular Pathways of Apoptosis.
  • Molecular and Cellular Biochemistry
  • Toxicology/Environmental Toxicology