Acute Oral Toxicity of Methyl-N,N'-dihexylethylene diaminemonocarbamate (CHR4) in Sprague-Dawley Rats

Abstract

The acute oral toxicity of methyl-N, N'-dihexylethylene diaminemonocarbamate (CHR4) was determined in male and female albino Sprague- Dawley rats administered a single dose by oral gavage. The median lethal doses (MLD) were 261 mg/kg in male and 251 mg/kg in female rats. The spectrum of observed clinical signs and their rapid onset were consistent with CHR4-induced cholinesterase inhibition. The signs and symptoms included diarrhea, salivation, and lacrimation, muscle weakness, changes in reflexes, convulsions, and disorientation. Lethality was observed only within the first eight hours after dosing and toxic signs were observed primarily within the first 34 hours after dosing. These results place CHR4 in the moderately toxic category.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 1990
Accession Number
ADA233007

Entities

People

  • Don W. Korte Jr.
  • Gerald F. Hiatt
  • Max Goldman

Organizations

  • Letterman Army Hospital

Tags

DTIC Thesaurus Topics

  • Biological Sciences
  • Biomedical Research
  • Body Weight
  • Data Storage Systems
  • Death
  • Digestive System Processes
  • Factor Analysis
  • Insect Repellents
  • Lethal Dosage
  • Medical Personnel
  • Military Research
  • Nervous System
  • Physiology
  • Quality Control
  • Seizures
  • Signs And Symptoms
  • Toxicology

Fields of Study

  • Medicine

Readers

  • Toxicology/Environmental Toxicology