Glucose-6-Phosphate Dehydrogenase Deficiency and Haemoglobinophaties in Resident of Arso PIR, Irian Jaya
Abstract
A population of 223 persons (Javanese & Irianese) was studies for glucose-6-phosphate dehydrogenase (G-6-PD) deficiency and hemoglobinopathies. 6 Irianese were found to be G-6-PD deficient. G-6-PD levels in these individuals ranged from 4-50% of minimum normal values. 5 cases of hemoglobinopathy were detected. 1 Irianese had a hemoglobinopathy consistent with hemoglobin-Lepore Hollandia. 3 Javanese subjects expressed a variant hemoglobin consistent in electrophoretic mobility with hemoglobin E and 1 Javanese subjects expressed a variant consistent with fetal hemoglobin. While these findings demonstrate the resistance in the study population of hematologic variants that may effect susceptibility to malaria, the percent of subjects with variants probably is not great enough to affect significantly the rate of malaria transmission within the population.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1990
- Accession Number
- ADA233073
Entities
People
- J. K. Baird
- M. Supriatman
- S. Ratiwayanto
- Tracy Jones
Organizations
- Naval Medical Research Center