Healing of Intraosseous Critical Size Defects in Long-Evans Rats
Abstract
Repair of rat critical-size craniotomy defects (CSDs) was compared with that of CSDs treated with either osteoconductive rat collagenous bone matrix (m), or osteoinductive partially purified bovine osteogenin, reconstituted with M (OG/m). Repair of all CSDs was similar histologically throughout the first three days, characterized by acute, then chronic inflammation and granulation tissue formation. Osteoclastic and osteoblastic activity at the margins of the defects subsided by day 28 in untreated and M- treated defects. Untreated CSDs gradually filled in with fibrous connective tissue which matured throughout 42 days. CSDs treated with M showed island of cartilage and bone embedded in connective tissue at day 9, which reached peak maturity by day 14. In contrast, cartilage and osteoblast were present in defects treated with OG/M at day 5. By day 9 cartilage and osteoid production were active. New bone formed at the edges of the defects showed hematopietic tissue by day 11; a complete bone bridge was established by day 21.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 10, 1991
- Accession Number
- ADA233529
Entities
People
- A. H. Reddi
- Jeffrey O. Hollinger
- Leslie J. Marden
- Nicholas Quigley
- Patrick Canan
Organizations
- United States Army Institute of Surgical Research