Evaluation of Dried Storage of Platelets and RBC for Transfusion: Lyophilization and Other Dehydration Techniques

Abstract

This project is based on the empirical development of processes whereby blood platelets and erythrocytes can be stabilized to withstand lyophilization for long-term dried storage as a transfusion resource for combat casualty care. The investigators bring together expertise in lyophilization techniques, blood banking practice, platelet physiology and liquid storage studies, and blood cell survival assessments. The second year of this grant was focused on three major efforts: extensive evaluation of paraformaldehyde- stabilized platelets (para-plts), development of new stabilization protocols (KMnO4, etc.), and application of new and existing stabilization protocols to RBC.

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Document Details

Document Type
Technical Report
Publication Date
Jan 31, 1991
Accession Number
ADA234135

Entities

People

  • Arthur P. Bode
  • Marjorie S. Read
  • Robert L. Reddick
  • Stein Holme
  • W. A. Heaton

Organizations

  • East Carolina University

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Adhesion
  • Albumins
  • Blood
  • Blood Cells
  • Blood Coagulation Factors
  • Blood Platelets
  • Blood Transfusions
  • Cell Physiological Processes
  • Cells
  • Cellular Structures
  • Combat Casualty Care
  • Electron Microscopy
  • Freeze Drying
  • Microscopes
  • Microscopy
  • North Carolina
  • Platelet Activation

Readers

  • Parasitology and Pharmacology of Malaria.
  • Systems Analysis and Design
  • Trauma or Military Medicine