Genetic Toxicity Assessment of 1,3-Dichlorotetrafluorobenzene

Abstract

1,3-Dichlorotetrafluorobenzene (DCFB), a fully substituted halogenated benzene, was evaluated using in vitro bioassays to assess its potential genotoxic activity. The assays conducted were the Ames salmonella/ microsomal mutagenicity assay, the Chinese hamster ovary (CHO) gene mutation assay, the CHO/sister chromatid exchange (SCE) and chromosome aberration assay, the BALB/c-3T3 cell transformation assay and an in vivo/in vitro unscheduled DNA synthesis assay. DCFB did not demonstrate genotoxic potential in any of the assays. Thus the results of the test battery would predict no genetic risk from exposure to DCFB.

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Document Details

Document Type
Technical Report
Publication Date
Nov 01, 1990
Accession Number
ADA234344

Entities

People

  • B. C. Myhr
  • D. C. Valentine
  • R. R. Young
  • R. S. Kutzman
  • T. E. Lawlor

Organizations

  • Armstrong Laboratory

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Anti-Bacterial Agents
  • Bacteria
  • Biomedical Research
  • Cancer
  • Cell Count
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Chemical Warfare Agents
  • Chemistry
  • Chromosome Structures
  • Culture Techniques
  • Epithelial Cells
  • Experimental Design
  • Genetics
  • Plant Oils
  • Statistical Analysis

Fields of Study

  • Biology
  • Chemistry

Readers

  • Molecular and genetic basis of cancer.
  • Toxicology/Environmental Toxicology

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech