Biological Significance of the Immune Response to HTLV-III/HAV

Abstract

Comprehensive studies have been conducted to determine seroreactivity of HIV infected individuals to well defined epitopes on the virus envelope. These have included regions antibodies. The principal neutralizing domain (PND) of HIV lies within the third hypervariable domain and is represented by a disulfide linked loop (residues 303-337). This region contains both variable and conserved epitopes. The ADCC targets are present in both gp120 and gp41 and are represented by conserved domains.

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Document Details

Document Type
Technical Report
Publication Date
Dec 14, 1990
Accession Number
ADA234622

Entities

People

  • Dani P. Bolognesi

Organizations

  • Duke University Hospital

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Amino Acids
  • Animals
  • Antibodies
  • Cells
  • Classification
  • Contracts
  • Glycoproteins
  • Hiv Infections
  • Identification
  • Infection
  • Laboratory Animals
  • Lymphocytes
  • Neutralization
  • Security
  • Vaccines
  • Viruses
  • Wound Infections

Fields of Study

  • Biology

Readers

  • Immunology
  • Molecular and Cellular Biochemistry