Methylphenidate and Pemoline: Effects on Sleepiness and Mood during Sleep Deprivation

Abstract

Thirty-six male subjects (mean age = 20.94) participated in a study of the effects of methylphenidate (10 mg every 6 hours; 8 doses) or pemoline (37.5 mg every 12 hours; 4 doses) in maintaining alertness during 64 hours of sleep deprivation. Subjective sleepiness was measured by a Visual Analog Scale (VAS), objective sleepiness by the number of lapses (intertap interval 3 seconds) on a 10 minute tapping task, and mood by the Profile of Mood States (POMs). Results indicate that 37.5 mg pemoline administered every 12 hours significantly reduced both subjective and objective sleepiness in sleep deprived subjects. Primarily during the circadian throughs but has little effect on self ratings of mood; while 10 mg of methylphenidate administered every 6 hours has no significant effect on these measures.

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Document Details

Document Type
Technical Report
Publication Date
Mar 04, 1991
Accession Number
ADA234659

Entities

People

  • H. Babkoff
  • L. T. Matteson
  • P. Naitoh
  • S. Hauser
  • T. L. Kelly

Organizations

  • Naval Health Research Center

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Central Nervous System
  • Classification
  • Deprivation
  • Diseases And Disorders
  • Dyssomnias
  • Intervals
  • Medical Personnel
  • Mental Disorders
  • Military Personnel
  • Nervous System
  • Ratings
  • Security
  • Situational Awareness
  • Sleep Deprivation
  • Statistical Analysis
  • Training
  • Underwater Demolition

Fields of Study

  • Psychology

Readers

  • Circadian Sleep-Wake Regulation and Chronobiology