Development of a Screening Procedure for Use in the Evaluation of Topical Protectants after Challenge with Vesicating Agents

Abstract

1,1' -Thiobis2-cloroethane (bis(2-chloroethyl)sulfide, sulfur mustard, H) causes skin, respiratory and eye injury land has been identified as being mutagenic and carcinogenic. The development of topical protectants that can decrease the effects of cutaneous exposure to vesicating chemical warfare agents or that may enhance the effectiveness of decontamination through limiting penetration to the skin should significantly enhance a soldier's ability to carry out his or her job in a chemically hostile environment. Preliminary in vivo studies with a small number of candidate topical protectants demonstrated that they could provide protection against several different chemical agents.

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Document Details

Document Type
Technical Report
Publication Date
Apr 01, 1991
Accession Number
ADA234947

Entities

People

  • Brenda Jacinto
  • Curtis Gadson
  • Jeffry S. Forster
  • Millard M. Mershon

Organizations

  • United States Army Medical Research Institute of Chemical Defense

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Biological Sciences
  • Biomedical Research
  • Chemical Agent Detection
  • Chemical Detectors
  • Chemical Warfare
  • Chemical Warfare Agents
  • Decontamination
  • Dermatologic Agents
  • Drug Therapy
  • Engineering
  • Eye Injuries
  • Fluoropolymers
  • Materials
  • Military Research
  • Standards
  • Test Methods

Readers

  • Environmental Engineering.
  • Irregular Warfare and Special Operations Cyberspace Operations against Adversarial Threats.
  • Toxicology/Environmental Toxicology