Lysosomal Changes in Renal Proximal Tubular Epithelial Cells of Male Sprague Dawley Rats Following Decalin Exposure

Abstract

Physiologic proteinuria is a characteristic feature of young adult male rats which may be associated with an androgen-dependent inefficiency of renal protein reabsorption and catabolism. The major component of the proteinuria is a low molecular weight glycoprotein called alpha 2U globulin. The principal cytoplasmic organelle involved with alpha 2U globulin metabolism is the lysosome. The physiologic proteinuria and metabolism of alpha 2U globulin have been associated with a potentially unique susceptibility of male rats to specific xenobiotic-induced nephrotoxicity. Exposure of male rats to compounds such as d-limonene, decalin, 2,2,4-trimethylpentane, and JP-5 jet fuel results in pathologic renal alteration.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 1990
Accession Number
ADA235138

Entities

People

  • Carl L. Alden
  • David J. Schaeffer
  • David R. Mattie
  • Joann C. Eurell
  • Thomas E. Eurell

Organizations

  • University of Illinois Urbana–Champaign

Tags

DTIC Thesaurus Topics

  • Alkanes
  • Catabolism
  • Cell Physiological Processes
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Cytoplasm
  • Electron Microscopy
  • Epithelial Cells
  • Fuels
  • Hydrocarbons
  • Medical Personnel
  • Metabolism
  • Organelles
  • Organic Chemistry
  • Pathology
  • Proteins

Fields of Study

  • Medicine

Readers

  • Cardiovascular Physiology
  • Molecular and Cellular Biochemistry
  • Petroleum Engineering