Assessment of the Development Toxicity of Zinc Naphthenate in Rats Phase 4
Abstract
This study was designed to detect any potential developmental toxicity and/or teratogenic hazard associated with the use of zinc naphthenate as a wood preservative. Oral administration of zinc naphthenate to rats during the major period of fetal organogenesis did not result in teratogenic effects. Transient maternal toxicity was confined to the highest dosage group (938 mg/kg/ day) and consisted of lethargy and lower body weight gain. Maternal treatment at that dosage level also produced a higher incidence of resorptions and lower average fetal body weight. Dams receiving zinc naphthenate, 94 or 188 mg/kg/day, were not effected; nor were their developing fetuses. Under the conditions of this study, zinc naphthenate was found to effect the developing fetus only at a dosage level which produced toxic signs in the maternal animal. In order to minimize human exposure, appropriate personal protection should be employed when handling all formulated wood preservatives, including those containing zinc naphthenate.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 28, 1991
- Accession Number
- ADA235308
Entities
People
- Mark W. Michie
- Mary P. Barlow
- Particia A. Beall
- Richard A. Angerhofer
Organizations
- United States Army Medical Command