Molecular Biological Studies on the Biogenesis of Human Cholinesterases in vivo and as Directed by Cloned Cholinesterase DNA Sequences

Abstract

Acetylcholinesterase (ACHE) is an enzyme long noted for its essential role in the termination of neurotransmission at cholinergic synapses and neuromuscular junctions. Because acetylcholinesterase is the target protein for a variety of neurotoxic compounds, including natural poisons, common agricultural insecticides, and chemical warfare agents, research on this enzyme in man has profound implications for human health and well-being. Together with the related but distinct protein butyrylcholinesterase (BCHE), it presents an intriguing model for the basic scientific study of tissue-specific and differential regulation of gene expression employing divergent pathways in protein biosynthesis.

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Document Details

Document Type
Technical Report
Publication Date
Oct 24, 1990
Accession Number
ADA235425

Entities

People

  • Hermona Soreq

Organizations

  • Hebrew University of Jerusalem

Tags

DTIC Thesaurus Topics

  • Brain
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Genetic Structures
  • Genetics
  • Medical Personnel

Fields of Study

  • Biology

Readers

  • Molecular Genetics
  • Neurotoxicology
  • Systems Analysis and Design