Human Erythrocyte as a Model for Investigating Muscarinic Agonists and Antagonists
Abstract
Cholinergic muscarine receptors have been identified in the brain (Schiller, 1979), neuromuscular junctions (Yamamura and Snyder, 1974) pylorus (Gaginella et al., 1980), cardiac aorta (Peterson and Schimerlik, 1982) and other tissues/organs by direct binding assays of radiolabeled cholinergic agonists or antagonists. It is well recognized that the cation channel, the anesthetic site, is coupled to cholinergic receptors (Aguilar et al., 1980). The cholinergic muscarinic agonists either stimulate cGMP production or inhibit cAMP production (Greengard, 1975). Recently numerous reports have alluded to the existence of four subtypes of muscarinic receptor that can be distinguished by their binding affinities and their amino acid sequences.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1991
- Accession Number
- ADA235578
Entities
People
- Lily C. Tang
Organizations
- Walter Reed Army Institute of Research