AFRRI Reports First Quarter, January-March 1991

Abstract

Ionizing radiation reduces the host's defenses to infection (1) and enhances its susceptibility to systemic infection due to endogenous and exogenous organisms. Klebsiella pneumoniae is one of the most frequent causes of gram-negative bacteremia, and is especially prevalent in immunocompromised patients. Therapy for severe systemic infection due to gram-negative bacteria generally involves the use of aminoglycosides in combination with beta lactam antibiotics. However, several recently developed quinolone compounds have exhibited high in vitro bactericidal activity against most gram negative bacteria. including K. pneumoniae. In this study, we evaluated the efficacy of oral therapy with several quinolones in a model of experimental septicemia due to orally ingested K pneumoniae in irradiated mice.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 1991
Accession Number
ADA235899

Entities

Organizations

  • Armed Forces Radiobiology Research Institute

Tags

DTIC Thesaurus Topics

  • Cells
  • Chemical Synthesis
  • Chemistry
  • Health Services
  • Medical Personnel
  • Organic Chemistry

Fields of Study

  • Medicine

Readers

  • Immunology
  • Microbial Pathology
  • Nuclear and Radiation Engineering.