A CTL Epitope on the Circumsporozoite Protein of P. Yoelii
Abstract
A vaccine model exists for protection against the preerythrocytic stages of malaria. Humans and rodents can be protected against sporozoite infection by immunization with radiation-attenuated sporozoites. There is evidence from different animal models that both antibodies and T cells may be involved in this immune response. However, when BALB/c mice are immunized with Plasmodium yoelii sporozoites, it appears that antibody alone plays a minor protective role, while CD8+T cells have critically important anti-sporozoite functions. The parasite antigens recognized by these protective CD8+ T cells have not been identified.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1990
- Accession Number
- ADA235902
Entities
People
- J. A. Berzofsky
- L. H. Miller
- M. F. Good
- R. A. Houghten
- W. R. Weiss
Organizations
- Naval Medical Research Center